Description
Targeting Immune Cell Signaling Pathway in Oncology. The main function of basophils is to degranulate upon specific signals. Typically, basophil degranulation is activated by complex of allergen bound to specific IgE via the high affinity receptor for IgE. Basophil degranulation and activation can be easily measured in flow cytometry by quantifying the expression of cell surface activation markers such as CD63. Allergic responses, autoimmune disorders and oncology are all comprised of signaling pathways that are also involved in modifying the activation status of basophils. Several key kinases that are molecular targets in drug discovery, such as PI3Kγ and PI3Kδ, SYK, BTK are main components in the basophil activation signaling pathways